Systemic lupus erythematosus (SLE) is an autoimmune disorder with heterogeneous clinical presentation and complex etiology involving the interplay between genetic, epigenetic, environmental and hormonal factors. These results indicate that CRP concentrations were increased in dogs with IMRD and ANA, but the increase was mild, similar to what has been observed in human SLE. Dogs with IMRD and ANA had higher CRP concentrations than the control dogs, but the concentrations were below the clinical decision limit for systemic inflammation for most of the IMRD dogs. Serum CRP concentrations were measured in 18 IMRD-affected NSDTRs and 19 healthy control NSDTRs using two different canine-specific CRP assays. The hypothesis was that CRP concentrations would be increased in dogs with IMRD compared to healthy dogs, but that the increase would be mild. The aim of the study was to investigate CRP in a group of NSDTRs with the SLE-related disorder IMRD.
However, in human SLE, CRP concentrations are often elevated but correlate poorly with disease activity they can be low in individual patients with active disease.
C-reactive protein (CRP), an acute phase protein, is a quantitative marker of inflammation for many diseases and is used for diagnosing and monitoring systemic inflammation in both humans and dogs. The clinical and diagnostic findings of IMRD indicate that it is an SLE-related disorder. Most, but not all, dogs with IMRD, have antinuclear antibodies (ANA), which are also commonly present in the autoimmune disease systemic lupus erythematosus (SLE). Nova Scotia Duck Tolling Retrievers (NSDTRs) are a dog breed often affected by immune-mediated rheumatic disease (IMRD), a disorder characterised by chronic stiffness and joint pain. The findings of this research may indicate a chronic systemic rheumatic disorder. This paper describes a disorder in Nova Scotia duck tolling retrievers where the clinical signs, ANA reactivity and response to corticosteroids strongly suggest that the disorder is immune-mediated. There was no association between the IIF-ANA results and the clinical signs or results of treatment. Most of the dogs were treated with corticosteroids, with the majority of the dogs (65%) showing good responses. Seventy per cent of the Tollers with signs of disease displayed a positive IIF-ANA test.
NOVA SCOTIA DUCK TOLLING RETRIEVER SKIN
Twenty-seven per cent of the dogs also showed muscle pain and 18% different skin symptoms. Routine radiographic examinations were performed on 11 dogs.Īll the Toller patients showed stiffness and lameness that had lasted for at least 14 days and displayed pain from several joints of extremities on manipulation. An IIF-ANA (antinuclear antibody) test and an assay for the presence of antibodies to Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato were performed, as well as some haematology, serum biochemistry and urine tests. All the dogs were thoroughly examined and followed for a period of 2 months - 4 years. The study included 33 Tollers with musculoskeletal signs and 20 healthy controls. The aim of this first clinical description of the disorder in Tollers was to describe the clinical manifestations and laboratory findings, as well as to try to identify a possible immune-mediated background of the disease and to show the outcome of treatment in 33 Tollers. A disease complex with chronic musculoskeletal signs, including stiffness and joint pain, and to which there is a strong predisposition in the canine breed Nova Scotia duck tolling retriever (Toller) has been recognized in Sweden.
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